Puffalo is a mutant that resembled an ordinary bison, but can inflate like a puffer fish.
- In the short episode "What was the Doctor thinking?", Peri and Entrée observed a herd of them. Entrée honked the golf cart's horn, causing the whole herd to inflate. One then rolled over the duo.
- The short they appeared in was after the episode "Bite, Shuffle and Moan".